Acs Chemical Biology

A Bispecific Antibody Engineering Strategy for Effective Dual-Target Degradation of Cell-Surface and Secreted Oncoproteins with Superior Antitumor Activit

Author: Zhang, Yishu; Ma, Jing; Zheng, Zhenting; Fang, Tong; Sun, Huanhuan; Li, Na; Cai, Xiaoqing

Journal: ACS CHEMICAL BIOLOGY. 2026; Vol. 21, Issue 4, pp. 863-875. DOI: 10.1021/acschembio.6c00123

Hepatocyte-Targeted Cyclic Peptide LYTACs for PCSK9 Degradation and LDL Cholesterol Metabolic Regulatio

Author: Feng, Bin; Shi, Yiling; Xu, Jingjie; Hu, Mingxing; Liang, Shanshan; Li, Yujue; Gan, Wei

Journal: ACS CHEMICAL BIOLOGY. 2026; Vol. 21, Issue 4, pp. 801-811. DOI: 10.1021/acschembio.6c00029

Li-BrU-seq: A Low-Input and Simplified Metabolic Labeling Method for Nascent RNA Sequencin

Author: Huang, Yi-Feng; He, Jun-Tong; Lan, Ye-Lin; Zhang, Zhi-Hao; Wu, Fu; Wang, Chen-Long; Wang, Qiu-Yu; Luo, Guan-Zheng; Zhang, Zhang

Journal: ACS CHEMICAL BIOLOGY. 2026; Vol. 21, Issue 3, pp. 601-612. DOI: 10.1021/acschembio.5c01011

Nuclear-m6A-Label-Seq Enables Transcriptome-Wide Nuclear m6A Profiling at Single-Base Resolutio

Author: Huang, Chenyang; Ying, Xiner; Shu, Xiao; Liu, Jianzhao

Journal: ACS CHEMICAL BIOLOGY. 2026; Vol. 21, Issue 3, pp. 613-625. DOI: 10.1021/acschembio.6c00014

Expedient Chemical Synthesis of Ufmylated Histones Using Chemoenzymatic C-Terminal Hydrazinolysis of Ubiquitin-Fold Modifier

Author: Liu, Xin; Chen, Cong; Li, Fang; Liu, Xiaotong; Lu, Chengpiao; Li, Yuanpeng; Peng, Shuai; Xu, Hongrui; Tian, Changlin; Xu, Guoqiang; Li, Jia-Bin

Journal: ACS CHEMICAL BIOLOGY. 2026; Vol. , Issue , pp. -. DOI: 10.1021/acschembio.6c00132

Degrade to Display: Coupling Checkpoint Degradation with Exogenous Antigen Presentation to Boost Antitumor Immunit

Author: Ma, Yicong; Jiang, Jianfei; Han, Yu

Journal: ACS CHEMICAL BIOLOGY. 2026; Vol. , Issue , pp. -. DOI: 10.1021/acschembio.6c00191

Selective Reduction of α,β-Unsaturated Carbonyls with Ketoreductas

Author: Liu, Xinxin; Wu, Dan; Xu, Hanxiao; Kong, Zhengqing; Fang, Yaxuan; Fan, Wencai; Chen, Lin; Zhu, Jin

Journal: ACS CHEMICAL BIOLOGY. 2026; Vol. , Issue , pp. -. DOI: 10.1021/acschembio.5c00743

Dynamic Control of RNA Structure and Function through Bioorthogonal Staudinger Chemistr

Author: Zhu, Li; Xiong, Wei; Yang, Silin; Qi, Qianqian; Liu, Xingyu; Zhou, Xiang; Tian, Tian

Journal: ACS CHEMICAL BIOLOGY. 2026; Vol. , Issue , pp. -. DOI: 10.1021/acschembio.6c00067

Decarboxylase Activity of an Antibiotic Biosynthesis Monooxygenase Family Protein in the Biosynthesis of the Type II Polyketide Murayaquinon

Author: Zhou, Jie; Lin, Lin; Gao, Yaojie; Gao, Yan; Zhu, Jinwei; Qu, Xudong; Deng, Zixin; Jiang, Ming

Journal: ACS CHEMICAL BIOLOGY. 2026; Vol. , Issue , pp. -. DOI: 10.1021/acschembio.5c00695

Chemical Probes Derived from Third-Generation EGFR-TKIs as Potential Companion Diagnostic Tools for Targeted Therap

Author: Lei, Qian; Li, Ying; Song, Chao; Yang, Na; Deng, Hui

Journal: ACS CHEMICAL BIOLOGY. 2026; Vol. , Issue , pp. -. DOI: 10.1021/acschembio.5c00870

Playing with the Molecules of Life

引用次数：38

SPR-Measured Dissociation Kinetics of PROTAC Ternary Complexes Influence Target Degradation Rate

引用次数：26

Directed Evolution of Split APEX2 Peroxidase

引用次数：23

Translation Termination Factor GSPT1 Is a Phenotypically Relevant Off-Target of Heterobifunctional Phthalimide Degraders

引用次数：20

Design and Characterization of SGK3-PROTAC an Isoform Specific SGK3 Kinase PROTAC Degrader

引用次数：17

Rapid and Reversible Knockdown of Endogenously Tagged Endosomal Proteins via an Optimized HaloPROTAC Degrader

引用次数：16

Dual Allosteric Inhibition of SHP2 Phosphatase

引用次数：16

Genetic Code Expansion in Animals

引用次数：15

Fluorescent Chemosensors as Future Tools for Cancer Biology

引用次数：14

Norbornene Probes for the Detection of Cysteine Sulfenic Acid in Cells

引用次数：13